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Microfabrication & Regenerative medicine

当該事業の前身である研究拠点形成事業Ａ「バイオ融合マイクロ・ ナノメカトロニクス国際研究拠点」（H24-28）の成果のひとつであるSMMIL-E (スマイリー、Seeding Microsystems in Medicine in Lille-European-Japanese Technologies against Cancer-)の一環として実施している。SMMIL-Eは、東京大学生産技術研究所が従来から実施運営してきた、フランス国立科学研究センター（CNRS）との日仏国際共同運営ラボＬＩＭＭＳが管轄する国際共同研究プロジェクトである。SMMiL-Eの運営は、東大生産研とCNRS、リール大学、および、オスカーランブレー癌センター病院との間に締結されたバイオエレクトロニクス技術の癌治療研究への応用に関する合意書に基づいてなされている。SMMIL-Eの主な研究活動は、フランス・リール市のオスカーランブレー癌センター病院の敷地内にある癌研究施設IRCL（L’Institut pour la Recherche sur le Cancer de Lille、リール癌研究所）内で行われている。

 

Publications

2019

  1. Teru Okitsu, Eric Leblanc, Dominique Collard, and Hiroyuki Fujita: SMMiL-E, Japanese Bio-MEMS Laboratory in France, and the Role of Scientific Direction，Sensors and Materials，2019, Vol. 31, No. 9, pp. 2907-2916
  2. Yurii Kutovyi, Ignacio Madrid, Ihor Zadorozhnyi, Nazarii Boichuk, Soo Hyeon Kim, Teruo Fujii, Laurent Jalabert, Andreas Offenhaeusser, Svetlana Vitusevich & Nicolas Clément: Noise suppression beyond the thermal limit with nanotransistor biosensors, Scientific Reports, 2020, Vol 10, 12678

 

2020

  1. Kai Takeuchi, Nobuyuki Takama, Rie Kinoshita, Teru Okitsu, Beomjoon Kim: Flexible and porous microneedles of PDMS for continuous glucose monitoring, Biomedical Microdevices, 2020, 22:79, https://doi.org/10.1007/s10544-020-00532-1
  2. Dominique Decanini, Abdelmounaim Harouri, Yoshio Mita, Beomjoon Kim, and Gilgueng Hwang: 3D micro fractal pipettes for capillary based robotic liquid handling, Review of Scientific Instruments, 2020, 91, 086104, https://doi.org/10.1063/5.0018456
  3. Hakjae Lee, Gwenaël Bonfante, Yui Sasaki, Nobuyuki Takama, Tsuyoshi Minami, Beomjoon Kim: Porous microneedles on a paper for screening test of prediabetes, Medical Devices & Sensors, 2020, Volume 3, Issue 4 e10109, https://doi.org/10.1002/mds3.10109 (cover page)
  4. Shu Okumura, Benediktus Nixon Hapsianto, Nicolas Lobato-Dauzier, Yuto Ohno, Seiju Benner, Yosuke Torii, Yuuka Tanabe, Kazuki Takada, Alexandre Baccouche, Marie Shinohara, Soo Hyeon Kim, Teruo Fujii and Anthony Genot: Morphological Manipulation of DNA Gel Microbeads with Biomolecular Stimuli, Nanomaterials, 2021, 11(2), 293, https://doi.org/10.3390/nano11020293

 

2021

  1. Yurii Kutovyi, Ignacio Madrid, Nazarii Boichuk, Soo Hyeon Kim, Teruo Fujii, Laurent Jalabert, Andreas Offenhaeusser, Svetlana Vitusevich and Nicolas Clément: Single-trap phenomena stochastic switching for noise suppression in nanowire FET biosensors, Japanese Journal of Applied Physics, 2021, 60, SBBG03
  2. Momoko Kumemura, Deniz Pekin, Vivek Anand Menon, Isabelle Van Seuningen, Dominique Collard and Mehmet Cagatay Tarhan: Fabricating Silicon Resonators for Analysing Biological Samples, Micromachines, 2021, 12(12), 1546, https://doi.org/10.3390/mi12121546
  3. Xiaobin Wu, Jongho Park, Siu Yu A. Chow, Maria Carmelita Z. Kasuya, Yoshiho Ikeuchi, Kazuaki Kudo, and Beomjoon Kim: Localised light delivery on melanoma cells using optical microneedles, Biomedical Optics Express, 2022, Vol. 13, No. 2, pp.1045-1060

 

2022

  1. Leilei Bao, Jongho Park, Boyu Qin & Beomjoon Kim: Anti‑SARS‑CoV‑2 IgM/IgG antibodies detection using a patch sensor containing porous microneedles and a paper‑based immunoassay, Scientific Reports, 2022, 12(1):10693, https://doi.org/10.1038/s41598-022-14725-6
  2. Okumura, G. Gines, N. Lobato-Dauzier, A. Baccouche, R. Deteix, T. Fujii, Y. Rondelez & A. J. Genot: Nonlinear decision-making with enzymatic neural networks, Nature, 2022, Volume 610, pp.496–501, DOI:10.1038/s41586-022-05218-7

 

2023~

  1. Rémy Gauthier, Nina Attik, Charlène Chevalier, Vincent Salles, Brigitte Grosgogeat, Kerstin Gritsch, Ana-Maria Trunfio-Sfarghiu: 3D Electrospun Polycaprolactone Scaffolds to Assess Human Periodontal Ligament Cells Mechanobiological Behaviour, Biomimetics, 2023, Vol.8, Iss.1, 108, https://doi.org/10.3390/biomimetics8010108
  2. Daniel Alcaide, Jean Cacheux, Aurélien Bancaud, Rieko Muramatsu, Yukiko T. Matsunaga: Solute transport in the brain tissue: what are the key biophysical parameters tying in vivo and in vitro studies together, Biomaterials Science, 2023, Vol.11, pp.3450-3460, https://doi.org/10.1039/D3BM00027C
  3. Jean Cacheux, Aurelien Bancaud, Daniel Alcaide, Jun-Ichi Suehiro, Yoshihiro Akimoto, Hiroyuki Sakurai, Yukiko T. Matsunaga: Endothelial tissue remodeling induced by intraluminal pressure enhances paracellular solute transport, iScience, 2023, Vol 26, Iss.7, 107141
  4. Jean Cacheux, Jose Ordonez-Miranda, Aurelien Bancaud, Laurent Jalabert, Masshiro Nomura, Yukiko T. Matsunaga: Asymmetry of tensile vs. compressive elasticity and permeability contributes to the regulation of exchanges in collagen gels, Science Advances, 2023, Vol.9, Iss.31, eadf9775, https://www.science.org/doi/10.1126/sciadv.adf9775
  5. Chensong Xu, Gwenaël Bonfante, Jongho Park, Vincent Salles, Beomjoon Kim: Fabrication of an electrospun polycaprolactone substrate for colorimetric bioassays, Biomedical Microdevices, 2023, Vol.25, Article No.23
  6. Jongho Park, Beomjoon Kim: Biotagging method for animal identification using dissolvable microneedle arrays prepared by customisable moulds, Scientific Reports, 2023, Vol.13, 22823,https://www.nature.com/articles/s41598-023-50343-6
  7. Jongho Park, Kotaro Shobayashi, Beomjoon Kim: Optical Microneedle–Lens Array for Selective Photothermolysis, Micromachines, 2024, Vol.15, Iss.6, 725, https://doi.org/10.3390/mi15060725
  8. 花本渉, ルフェーブル アントニー・朴鍾淏・ヴィニョン ドゥヴァレ アンソフィ, デレン ナディラー,モティエ ローラン, 金範埈 (Wataru Hanamoto, Anthony Lefebvre, Jongho Park, Anne-Sophie Vignon Dewalle, Nadira Delhem, Laurent Motier, Beomjoon Kim): 光線力学治療のための光感受性物質と光を同時に伝達できるオプティカルマイクロニードルレンズアレイ(Optical Microneedle Lens Array Capable of Simultaneously Transmitting Light and Light Sensitive Substances for Photodynamic Therapy), 生産研究, 2024, Vol.76, Iss.2, pp.125-128
  9. Jean Cacheux, Tadaaki Nakajima, Daniel Alcaide, Takanori Sano, Kotaro Doi, Aurélien Bancaud, Yukiko T. Matsunaga: Protocol for fabricating and characterizing microvessel on-a-chip for human umbilical vein endothelial cells, STAR Protocols, 2024, Vol.5, Iss.2, 102950
  10. Heyi Jing, Jongho Park, Beomjoon Kim: Fabrication of a Polyglycolic Acid Porous Microneedle Array Patch Using the Non-Solvent Induced Phase Separation Method for Body Fluid Extraction, Nano Select, Wiley-VCH GmbH, 2024, Volume 5, Issue 10, Oct.30, pp. 1-14, https://doi.org/10.1002/nano.202400145
  11. Jongho Park, Jingzong Zhang, and Beomjoon Kim: Development of optical microneedle-lens array for photodynamic therapy, Biomedical Microdevices, 2025, vol. 27, 6, https://doi.org/10.1007/s10544-025-00735-4